Tirzepatide
Also known as · LY3298176 · Mounjaro · Zepbound · Dual GIP/GLP-1 receptor agonist
- EvidenceApproved
- CategoryMetabolic / diabetes / obesity
- RoutesubQ
- Half-life~5 days (once-weekly dosing)
- Form
- Lyophilized powder
- Purity
- ≥98% (HPLC)
- Molecular formula
- C225H348N48O68
- Molecular weight
- 4813.5 g/mol
- CAS number
- 2023788-19-2
- Sequence
- 39-residue lipidated peptide (Aib, C20 acyl side chain)
- COA
- Available on request
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01 / Research summary
What the literature reports
Tirzepatide (LY3298176) is an FDA-approved 39-residue lipidated peptide sold as Mounjaro (type 2 diabetes) and Zepbound (obesity). It is a dual agonist of the GIP and GLP-1 receptors.
Cellaire classifies Tirzepatide as FDA-approved. The FDA Mounjaro label indicates it as an adjunct to diet and exercise for glycemic control in type 2 diabetes, dosed subcutaneously once weekly starting at 2.5 mg, escalating in 2.5 mg increments after ≥4 weeks to a maximum of 15 mg. The label carries a boxed warning for thyroid C-cell tumors observed in rats.
02 / Reconstitution
Reconstitution reference
Illustrative unit math for a 20 mg vial reconstituted with 2 mL bacteriostatic water. This is not a dose recommendation.
03 / Overview
Molecular overview
Tirzepatide is a 39-residue peptide with Aib substitutions at positions 2 and 13 and a C20 fatty-diacid on Lys20. The C-terminus is a serinamide.
The C20 acyl chain binds circulating albumin, extending the plasma half-life to roughly 5 days and supporting once-weekly dosing.
As a dual GIP/GLP-1 agonist, tirzepatide activates two incretin receptors simultaneously. The label documents dose-dependent HbA1c and body-weight reductions in phase-3 SURPASS and SURMOUNT trials.
The FDA declared the tirzepatide shortage resolved in October 2024, closing the 503A compounding pathway. Tirzepatide is a prescription drug and cannot legally be sold as a research chemical for human use.
04 / References